| Bioactivity | Waldiomycin is an antibiotic found in Streptomyces sp. MK844-mF10 that has inhibitory effects on low GC-content Gram-positive bacteria. Waldiomycin inhibits the activity of WalK kinase by targeting its ATP-binding domain, thereby blocking the WalK/WalR signal transduction system, which plays a role in cell growth and division[1][2]. |
| CAS | 1342200-33-2 |
| Formula | C38H38O13 |
| Molar Mass | 702.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Igarashi, et al. Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10. The Journal of antibiotics 66.8 (2013): 459-464. [2]. Ishikawa, et al. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. The Journal of Antibiotics (2024): 1-11. |
Waldiomycin
CAS: 1342200-33-2 F: C38H38O13 W: 702.70
Waldiomycin is an antibiotic found in Streptomyces sp. MK844-mF10 that has inhibitory effects on low GC-content Gram-pos
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