| Bioactivity | Waixenicin A is a potent TRPM7 inhibitor with an IC50 value of 16 nM. Waixenicin A shows antiproliferative activity. Waixenicin A induces cell cycle arrest at G0/G1 phase[1][2]. |
| Invitro | Waixenicin A (0-100 µM；48 小时) 显示抗增殖活性，对 RBL1 细胞的 IC50 值为 3.2 µM[2]。Waixenicin A (0, 0.3, 3.3, 10 µM; 2 h) 以剂量依赖性方式诱导细胞周期停滞在 G0/G1 期[2]。 Cell Cycle Analysis[2] Cell Line: |
| Name | Waixenicin A |
| Formula | C24H34O6 |
| Molar Mass | 418.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Steinborn C, et al. Total Syntheses of (+)-Waixenicin A, (+)-9-Deacetoxy-14,15-deepoxyxeniculin, and (-)-Xeniafaraunol A. J Am Chem Soc. 2023 May 31;145(21):11811-11817. [2]. Zierler S, et al. Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J Biol Chem. 2011 Nov 11;286(45):39328-35. |