| Bioactivity | WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells[1]. |
| Invitro | WRR139（0.01-100 μM；1 小时）在体外抑制 NGLY1 并损害 HEK293 细胞中 Nrf1 的加工[1]。WRR139（5 μM；18 小时）破坏 HEK293 细胞中的 Nrf1 加工、定位和激活[1]。WRR139（1 μM；24 小时）以 NGLY1 依赖的方式增强 Carfilzomib 在 U266、H929 和 Jurkat 细胞中的细胞毒性[1]。 |
| Name | WRR139 |
| CAS | 2138924-36-2 |
| Formula | C25H32N2O4S |
| Molar Mass | 456.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. |