| Bioactivity | WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression[1]. |
| Target | IC50:2.305 µM (WRN) |
| Invitro | WRN inhibitor 6 (compound 3ci) (0-100 µM; 72 h) 诱导 HCT116 和 SW620 细胞DNA损伤与细胞凋亡，IC50 值分别为 2.305、16.58 µM[1].WRN inhibitor 6 (0, 2.5, 5, 10 µM; 3, 27 h) 以剂量依赖性方式增加 HCT116 细胞中 p-p53、P-Chk2、γH2AX 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> WRN inhibitor 6 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | WRN inhibitor 6 (20 mg/kg for p.o.; 5 mg/kg for i.v.) 在小鼠体内的口服利用度较低，F 为 11.43%，静脉注射半衰期短，为 0.17 小时[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C29H34O5S |
| Molar Mass | 494.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang H, et al. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability. Bioorg Med Chem. 2024 Feb 15;100:117588. |