| Bioactivity | WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function[1]. |
| Sequence | Chain1: Cys-Ser-Trp-Met-Arg-Leu-Lys Chain2: Cys-Ser-Trp-Met-Arg-Leu-Lys (Disulfide bridge: Chain1 Cys1-Chain2 Cys1) |
| Shortening | Chain1: CSWMRLK Chain2: CSWMRLK (Disulfide bridge: Chain1 Cys1-Chain2 Cys1) |
| Formula | C80H130N24O18S4 |
| Molar Mass | 1844.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gilliam A J H, et al. Affinity-guided design of caveolin-1 ligands for deoligomerization[J]. Journal of medicinal chemistry, 2016, 59(8): 4019-4025. |
WL 47 dimer
CAS: F: C80H130N24O18S4 W: 1844.30
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity
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