| Bioactivity | WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure[1]. |
| CAS | 1067654-70-9 |
| Formula | C35H38Cl2N6O |
| Molar Mass | 629.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction |