| Bioactivity | WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia[1]. |
| Target | Widely Interspaced Zinc Finger Motifs (WIZ) |
| Invitro | WIZ degrader 3 上调胎儿血红蛋白基因 (HBG1/2) 和诱导胎儿血红蛋白 (HbF) 在人原代红细胞中的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> WIZ degrader 3 相关抗体: |
| CAS | 2839637-72-6 |
| Formula | C18H23N5O3 |
| Molar Mass | 357.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. BECKWITH IREJ, et al. Benzisoxazole derivatives and uses thereof. WO2022195355A1. |
WIZ degrader 3
CAS: 2839637-72-6 F: C18H23N5O3 W: 357.41
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ
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