| Bioactivity | WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1]. | ||||||||||||
| Invitro | WEHI-9625 (0-10 µM; Mcl1−/−Bax−/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax−/−, but not Bak−/−, cells[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | WEHI-9625 | ||||||||||||
| CAS | 2595314-46-6 | ||||||||||||
| Formula | C34H27NO5S2 | ||||||||||||
| Molar Mass | 593.71 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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WEHI-9625
CAS: 2595314-46-6 F: C34H27NO5S2 W: 593.71
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2
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