WEE1-IN-7_product_DataBase

Bioactivity	WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC50 value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity[1].
Target	IC50: 2.1 nM (WEE1)
Invitro	WEE1-IN-7 (compound 12h) 抑制细胞活力，对 A427 和 Lovo 细胞的 IC50 值分别为 84 和 82 nM[1]。WEE1-IN-7 (0-800 nM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> WEE1-IN-7 相关抗体: Apoptosis Analysis[1] Cell Line:
In Vivo	WEE1-IN-7 (60 mg/kg; p.o.; daily for 27 days) 在 Lovo CDX 异种移植小鼠模型中表现出抗肿瘤活性，肿瘤生长抑制率 (TGI) 为 88%[1]。药代动力学分析[1]. Admin.
CAS	2924006-98-2
Formula	C28H28N10O
Molar Mass	520.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Y, et al. Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy. J Med Chem. 2024 Jun 7.

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