| Bioactivity | WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 (HY-16993), a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma[1]. | |||||||||
| Target | WDR5 | |||||||||
| Invitro | WDR5-IN-6 (compound 19) 抑制 IMR32 和 LAN5 细胞的增殖，EC50 值分别为 12.34 和 14.89 μM，对 SK-N-AS 细胞有中等抑制作用，在 20 μM时对 HEK293T 细胞没有影响[1]。 | |||||||||
| Name | WDR5-IN-6 | |||||||||
| CAS | 326901-92-2 | |||||||||
| Formula | C13H8Cl2N2O2S | |||||||||
| Molar Mass | 327.19 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Han QL, et al. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol Sin. 2023 Apr;44(4):877-887. |
WDR5-IN-6
CAS: 326901-92-2 F: C13H8Cl2N2O2S W: 327.19
WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines
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