| Bioactivity | WAY 629 hydrochloride is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 hydrochloride decreases feeding behavior[1][2]. |
| In Vivo | WAY 629 hydrochloride (30 mg/kg; i.p.) 降低大鼠的进食行为[1]。WAY 629 hydrochloride (30 mg/kg; i.p.) 降低小鼠大脑中 NPY mRNA 的表达[2]。 Animal Model: |
| Name | WAY 629 hydrochloride |
| CAS | 57756-44-2 |
| Formula | C15H19ClN2 |
| Molar Mass | 262.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. [2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28. |