WAAG-3R TFA_product_DataBase

Bioactivity	WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.)[1].
Sequence	{Abz}-Thr-Glu-Gly-Glu-Ala-Arg-Gly-Ser-Val-Ile-{Dpa}-Lys-Lys-NH2
Shortening	{Abz}-TEGEARGSVI-{Dpa}-KK-NH2
Formula	C69H109N23O24.xC2HF3O2
Molar Mass	1644.74 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. De Savi C, et al. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis[J]. Bioorganic & medicinal chemistry letters, 2011, 21(5): 1376-1381.

PeptideDB