| Bioactivity | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. | ||||||||||||
| Invitro | W146 is a S1PR1 antagonist with a Ki of ~70-80 nM[1]. W146 pretreatment significantly increases activated cleaved caspase-3 levels. The reduced EPCs apoptosis which induced by S1P is completely abolished after treatment with W146[2]. Apoptosis Analysis[2] Cell Line: | ||||||||||||
| Name | W146 | ||||||||||||
| CAS | 909725-61-7 | ||||||||||||
| Formula | C16H27N2O4P | ||||||||||||
| Molar Mass | 342.37 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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