W-5 hydrochloride_product_DataBase

Bioactivity	W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912)[1]sup>[2].
Target	IC50: 240 µM (phosphodiesterase)
Invitro	W-5 hydrochloride (40 µM; 24 h; incubation with 10 μg/ml of apolipoprotein A-I (apoA-I)) 可增加胆固醇和胆碱磷脂的流出[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> W-5 hydrochloride 相关抗体:
CAS	61714-25-8
Formula	C16H23ClN2O2S
Molar Mass	342.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Suzuki S, et al. Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. J Cardiovasc Pharmacol. 2000 Nov;36(5):609-16. [2]. Yokokura S, et al. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC Cancer. 2014 Nov 26;14:882.

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