| Bioactivity | Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1]. |
| Target | pKi: 9.5 (NK1, rat), 10.6 (NK1, human) |
| Name | Vofopitant dihydrochloride |
| CAS | 168266-51-1 |
| Formula | C21H25Cl2F3N6O |
| Molar Mass | 505.36 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53. |
Vofopitant dihydrochloride
CAS: 168266-51-1 F: C21H25Cl2F3N6O W: 505.36
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) recepto
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