Vitamin U chloride_product_DataBase

Bioactivity	Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5].
Invitro	Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1].Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1].Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2].Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3]. Cell Proliferation Assay[1] Cell Line:
In Vivo	Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats[4].Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5]. Animal Model:
Name	Vitamin U chloride
CAS	1115-84-0
Formula	C6H14ClNO2S
Molar Mass	199.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Won-Serk Kim, et al. Accelerated wound healing by S-methylmethionine sulfonium: evidence of dermal fibroblast activation via the ERK1/2 pathway. Pharmacology. 2010;85(2):68-76. [2]. Ilona Rácz, et al. S-methylmethionine reduces cell membrane damage in higher plants exposed to low-temperature stress. J Plant Physiol. 2008 Sep 29;165(14):1483-90. [3]. Na Young Lee, et al. Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines. Ann Dermatol. 2012 Feb;24(1):39-44. [4]. Ertan Celik, et al. Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis. Toxicol Mech Methods. 2021 Oct;31(8):600-608. [5]. Dileknur Topaloglu, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. J Biochem Mol Toxicol. 2022 Sep;36(9):e23124.

PeptideDB

Vitamin U chloride

CAS: 1115-84-0 F: C6H14ClNO2S W: 199.70