| Bioactivity | Verticillin A is a selective HMTase inhibitor. Verticillin A inhibits SUV39H1, SUV39H2, G9a, HTM, MLL1 and GLP. Verticillin A is a MEK inhibitor. Verticillin A induces DNA damage and apoptosis. Verticillin A has anticancer effects against various cancers. Verticillin A is also an antibiotic[1][2][3]. |
| CAS | 889640-30-6 |
| Formula | C30H28N6O6S4 |
| Molar Mass | 696.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Salvi A, et al. Verticillin A Causes Apoptosis and Reduces Tumor Burden in High-Grade Serous Ovarian Cancer by Inducing DNA Damage. Mol Cancer Ther. 2020 Jan;19(1):89-100. [2]. Schenke D, et al. Verticillin A is likely not produced by Verticillium sp. J Antibiot (Tokyo). 2011 Jul;64(7):523-4. [3]. Guan Y, et al. Verticillin A increases the BIMEL/MCL-1 ratio to overcome ABT-737-resistance in human colon cancer cells by targeting the MEK/ERK pathway. Biochem Biophys Res Commun. 2021 Aug 27;567:22-28. |
Verticillin A
CAS: 889640-30-6 F: C30H28N6O6S4 W: 696.84
Verticillin A is a selective HMTase inhibitor. Verticillin A inhibits SUV39H1, SUV39H2, G9a, HTM, MLL1 and GLP. Verticil
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