| Bioactivity | Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD)[1]. |
| Invitro | Verproside（2.5-20 μM；持续 2 小时）显着降低 5-20 μM 范围内 IKKα/β、IκBα 和 TAK1 的磷酸化水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Verproside 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Verproside（胃内；30 mg/kg；48 小时）显着降低接受 verproside 治疗的小鼠的免疫球蛋白 E (IgE) 水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 50932-20-2 |
| Formula | C22H26O13 |
| Molar Mass | 498.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75. [2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10. |