| Bioactivity | AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. | ||||||||||||
| Target | IC50: 0.9 nM (Glucocorticoid receptor) | ||||||||||||
| Invitro | AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM). | ||||||||||||
| In Vivo | AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema[1]. | ||||||||||||
| Name | Velsecorat | ||||||||||||
| CAS | 1196509-60-0 | ||||||||||||
| Formula | C32H32F2N4O6 | ||||||||||||
| Molar Mass | 606.62 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hemmerling M, et al. Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases. J Med Chem. 2017 Oct 26;60(20):8591-8605. |