| Bioactivity | Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg[1][2]. |
| CAS | 3187-52-8 |
| Formula | C17H16O5 |
| Molar Mass | 300.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang X, et al. Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. J Biol Chem. 1996 Jul 26;271(30):17785-90. [2]. Kurosawa K, et al. Variabilin, a 6a-hydroxypterocarpan from Dalbergia variabilis[J]. Phytochemistry, 1978, 17(8): 1417-1418. |