| Bioactivity | Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil dihydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM respectively, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil dihydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil dihydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6]. |
| Invitro | Vardenafil dihydrochloride specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 value of 0.7 nM[1].Vardenafil dihydrochloride increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow[3]. |
| Name | Vardenafil dihydrochloride |
| CAS | 224789-15-5 |
| Formula | C23H34Cl2N6O4S |
| Molar Mass | 561.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Vardenafil dihydrochloride
CAS: 224789-15-5 F: C23H34Cl2N6O4S W: 561.52
Vardenafil dihydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7
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