| Bioactivity | Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC50 of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC50 of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.)[1]. |
| CAS | 137863-17-3 |
| Formula | C25H31N5O3 |
| Molar Mass | 449.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bühlmayer P, et al., Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(1): 29-34. |
Valsartan methyl ester
CAS: 137863-17-3 F: C25H31N5O3 W: 449.55
Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active
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