| Bioactivity | Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease[1]. |
| In Vivo | Valiglurax (VU0652957; 0.3-30 mg/kg; po) 以剂量依赖性方式逆转 haloperidol (HY-14538) 诱导的大鼠僵直症 (HIC)[1]。 Animal Model: |
| Name | Valiglurax |
| CAS | 1976050-09-5 |
| Formula | C16H10F3N5 |
| Molar Mass | 329.28 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Panarese JD, et, al. Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease. ACS Med Chem Lett. 2018 Oct 16;10(3):255-260. |
Valiglurax
CAS: 1976050-09-5 F: C16H10F3N5 W: 329.28
Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of
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