| Bioactivity | Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3]. |
| Invitro | Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | Validamycin A |
| CAS | 37248-47-8 |
| Formula | C20H35NO13 |
| Molar Mass | 497.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
Validamycin A
CAS: 37248-47-8 F: C20H35NO13 W: 497.49
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygro
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.