| Bioactivity | Vadocaine (OR K-242), an orally active antitussive compound, is a local anesthetic[1]. |
| In Vivo | 在豚鼠中，Vadocaine（2.5 mg/kg；口服）可将二氧化硫或氨引起的咳嗽发作减少约 70%[1]。在猫中，Vadocaine（3 mg/kg；静脉注射）可在 10 分钟内抑制约 80% 由气管机械刺激引发的咳嗽反射[1]。浓度为 0.25% 和 0.5% 的 Vadocaine 会导致豚鼠风团制剂局部麻醉，浓度为 0.5% 的 Vadocaine 会导致豚鼠角膜局部麻醉[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 72005-58-4 |
| Formula | C18H28N2O2 |
| Molar Mass | 304.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. P T Männistö, et al. Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models. Arzneimittelforschung. 1988 Apr;38(4A):598-604. |