VUF11207 fumarate_product_DataBase

Bioactivity	VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1].
Invitro	VUF11207 fumarate (0.17 nM; 5 days) inhibits RANKL‑ and TNF‑α‑induced osteoclastogenesis through CXCL12 inhibition in osteoclast precursor cells[1].VUF11207 fumarate inhibits osteoclastogenesis by suppressing phosphorylation of erk[1]. Cell Viability Assay[1] Cell Line:
In Vivo	VUF11207 fumarate (100 µg/day; s.c.; single daily for 5 days) inhibits LPS‑induced osteoclastogenesis, bone resorption and production of RANKL and TNF‑α in mice[1]. Animal Model:
Name	VUF11207 fumarate
CAS	1785665-61-3
Formula	C31H39FN2O8
Molar Mass	586.65
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92. [2]. Nugraha AP, et al. C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. Mol Med Rep. 2022 Mar;25(3):78.

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