VUF 5681 dihydrobromide_product_DataBase

Bioactivity	VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].
Invitro	VUF 5681 dihydrobromide (10 μM) 阻断了脑组织中硫哌丁胺的刺激作用[1]。VUF 5681 dihydrobromide (100 nM) 在 CHO-H3-SPAP 细胞中抑制其它的激动剂[2]。 0 --> VUF 5681 dihydrobromide 相关抗体:
Name	VUF 5681 dihydrobromide
CAS	639089-06-8
Formula	C11H21Br2N3
Molar Mass	355.11
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. [2]. Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.

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