| Bioactivity | VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2]. |
| In Vivo | VU6010572 (3 mg/kg; i.p.) shows robust efficacy[1].VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects[2]. Animal Model: |
| Name | VU6010572 |
| CAS | 2126784-39-0 |
| Formula | C20H18FNO3 |
| Molar Mass | 339.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. [2]. Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST |
VU6010572
CAS: 2126784-39-0 F: C20H18FNO3 W: 339.36
VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS pen
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This product is for research use only, not for human use. We do not sell to patients.