| Bioactivity | VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats[1]. |
| Target | EC50: 120 nM (hM4) |
| CAS | 2170550-99-7 |
| Formula | C14H13ClN4O |
| Molar Mass | 288.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Capstick R A, et al. Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile[J]. ACS Medicinal Chemistry Letters, 2024. |
VU6008677
CAS: 2170550-99-7 F: C14H13ClN4O W: 288.73
VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P4
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