| Bioactivity | VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. VU591 can be used for neurological research with HY-108585 (the equivalent of VU591 hydrochloride)[1]. |
| Target | IC50: 0.24 μM (ROMK). |
| Invitro | VU591 is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability[1]. |
| In Vivo | VU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST[2]. Animal Model: |
| Name | VU591 |
| CAS | 1222810-74-3 |
| Formula | C16H12N6O5 |
| Molar Mass | 368.30 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. [2]. Masayoshi Okada, et al. Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. PLoS One. 2020 Nov 13;15(11):e0233815. |
VU591
CAS: 1222810-74-3 F: C16H12N6O5 W: 368.30
VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μ
Data collection：peptidedb@qq.com
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