| Bioactivity | APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research[1]. |
| Invitro | NAPE-PLD activator (VU533) (0.1-30 μM，24小时) 对 RAW264.7 和 HepG2 细胞无细胞毒性[1]。NAPE-PLD activator (0.1-30 μM，24小时) 在 RAW264.7 细胞和 HepG2 细胞中以浓度依赖性方式增加 Nape-pld 活性[1]。NAPE-PLD activator (10 μM, 6小时) 增加从野生型小鼠体内分离的骨髓衍生巨噬细胞 (BMDM) 的胞葬作用[1]。 0 --> VU533 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Name | VU533 |
| CAS | 923417-09-8 |
| Formula | C21H22FN3O3S2 |
| Molar Mass | 447.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. |