| Bioactivity | VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1]. | |||||||||
| Target | EC50: 5.1 µM (GIRK2), 5.2 µM (GIRK1/2) | |||||||||
| Name | VU0529331 | |||||||||
| CAS | 1286725-49-2 | |||||||||
| Formula | C22H20N6O | |||||||||
| Molar Mass | 384.43 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13. |
VU0529331
CAS: 1286725-49-2 F: C22H20N6O W: 384.43
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK
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