| Bioactivity | VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1]. |
| Name | VU0453379 hydrochloride |
| Formula | C26H35ClN4O2 |
| Molar Mass | 471.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. |
VU0453379 hydrochloride
CAS: F: C26H35ClN4O2 W: 471.03
VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (
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