VU0405601_product_DataBase

Bioactivity	VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from dofetilide (HY-B0232)-induced ventricular tachycardia[1][2].
Target	KV11.1
Invitro	VU0405601 (5 µM；在 100 nm dofetilide之前预处理 30 分钟) 保护心脏组织免受多非利特 (HY-B0232) 诱发的室性心动过速[2]。VU0405601 (50 µM) 可用作 hERG 激动剂并增加测试脉冲和尾电流,使 dofetilide 的IC50 值从38.7 nm提高到76.3 nm[2]。
Name	VU0405601
CAS	712325-30-9
Formula	C17H13BrN2O2
Molar Mass	357.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Egly CL, et al. A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants. Mol Pharmacol. 2022 Apr;101(4):236-245. [2]. Potet F, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. J Biol Chem. 2012 Nov 16;287(47):39613-25.

PeptideDB