| Bioactivity | VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases[1]. |
| Target | EC50: 830 nM (mAChR M1) |
| CAS | 1222834-53-8 |
| Formula | C19H14FN3O2 |
| Molar Mass | 335.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. |
VU0366369
CAS: 1222834-53-8 F: C19H14FN3O2 W: 335.33
VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can
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