VU0152100_product_DataBase

Bioactivity

VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator (permeable to the blood-brain barrier). VU0152100 reverses Amphetamine-induced hypermotility in rats and increased levels of extracellular dopamine in nucleus accumbens and caudate-putamen. VU0152100 has good research potential in psychosis and cognitive impairment associated with mental disorders such as schizophrenia[1][2].

In Vivo

VU0152100 (10, 30, 56.6 mg/kg; i.p; single) 逆转安非他命诱导的大鼠过度运动[1]。VU0152100 (10, 30, 56.6 mg/kg; i.p.; single) 阻断安非他明诱导的对大鼠获得情境性恐惧调节和声学惊吓反射的前脉冲抑制的干扰[1]。VU0152100 能逆转安非他明诱导的伏隔核和尾状核-壳核中细胞外多巴胺水平的增加[1]。 Animal Model:

Name

VU0152100

CAS

409351-28-6

Formula

C18H19N3O2S

Molar Mass

341.43

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Byun NE, et al. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology. 2014 Jun;39(7):1578-93. [2]. Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

PeptideDB

VU0152100

CAS: 409351-28-6 F: C18H19N3O2S W: 341.43