| Bioactivity | VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site, rather than directly competing with the binding site of ACh, thereby enhancing the activity of the receptor. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease[1]. |
| CAS | 312622-77-8 |
| Formula | C19H21N3O7 |
| Molar Mass | 403.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marlo J E, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity[J]. Molecular pharmacology, 2009, 75(3): 577-588. |
VU0090157
CAS: 312622-77-8 F: C19H21N3O7 W: 403.39
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increa
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