| Bioactivity | VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) [1]. |
| Invitro | VU0038882 (‘882) (40 μM) 暴露导致 CPIII 在S. aureus 中积累[1].VU0038882 (0-10 μM) 在体外激活来自革兰氏阳性细菌的 CgoX[1]。VU0038882 (50 μM) 在革兰氏阳性病原体中诱导光敏性[1]。VU0038882 导致大量血红素积累，导致 S. aureus 中的 HssRS 激活[1]。VU0038882 导致革兰氏阳性菌光敏化，减少体内细菌负荷[1]。 |
| Name | VU0038882 |
| CAS | 429653-28-1 |
| Formula | C17H12N2O2 |
| Molar Mass | 276.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mao Y, et al. Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma. Eur J Med Chem. 2023;257:115489. |
VU0038882
CAS: 429653-28-1 F: C17H12N2O2 W: 276.29
VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Posi
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