VU 6008667_product_DataBase

Bioactivity	VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1].
Target	IC50: 1.2 μM (Human M5); 1.6 μM (Rat M5)
In Vivo	VU 6008667(1 mg/kg或者3mg/kg，口服作用于大鼠）较小的体积（Vss = 7.4 L/kg）和较高的清除率，显示半衰期为2.3小时（t1/2 = 2.3 hr),CLp = 82 mL/min/kg，显示口服生物利用度为17%(17％F)[1]。 Animal Model:
Name	VU 6008667
CAS	2092923-21-0
Formula	C24H17ClF2N2O2
Molar Mass	438.85
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reference	[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

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