| Bioactivity | VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM[1]. |
| Invitro | VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels[2]. Western Blot Analysis[2] Cell Line: |
| Name | VU-1545 |
| CAS | 890764-63-3 |
| Formula | C22H15FN4O3 |
| Molar Mass | 402.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tomas de Paulis, et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem. 2006 Jun 1;49(11):3332-44. [2]. J G Doria, et al. Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease. Br J Pharmacol. 2013 Jun;169(4):909-21. |