| Bioactivity | VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. | ||||||||||||
| Target | EC50: 1.16 μM (mAChR5). | ||||||||||||
| Invitro | VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1]. | ||||||||||||
| Name | VU 0238429 | ||||||||||||
| CAS | 1160247-92-6 | ||||||||||||
| Formula | C17H12F3NO4 | ||||||||||||
| Molar Mass | 351.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. |
VU 0238429
CAS: 1160247-92-6 F: C17H12F3NO4 W: 351.28
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50
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