VTSEGAGLQLQK-13C6,15N2 TFA_product_DataBase

Bioactivity	VTSEGAGLQLQK-13C6,15N2 (TFA) is the 13C- and 15N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect[1][2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 0 --> VTSEGAGLQLQK-13C6,15N2 TFA 相关抗体:
Name	VTSEGAGLQLQK-13C6,15N2 TFA
Sequence	Val-Thr-Ser-Glu-Gly-Ala-Gly-Leu-Gln-Leu-Gln-{Lys-13C6,15N2} (TFA salt)
Shortening	VTSEGAGLQLQ-{Lys-13C6,15N2} (TFA salt)
Formula	C4613C6H91N1315N2O19.xC2HF3O2
Molar Mass	1238.31 (free acid)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bronsema KJ, et al. Absolute quantification of the total and antidrug antibody-bound concentrations of recombinant human α-glucosidase in human plasma using protein G extraction and LC-MS/MS. Anal Chem. 2015 Apr 21;87(8):4394-401.

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