| Bioactivity | VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2]. | ||||||||||||
| Invitro | VT104 (0-1000 nM) 抑制 NF2 突变/缺陷细胞系的增殖[1]。 | ||||||||||||
| In Vivo | VT104 (0.3-3 mg/kg; p.o.; NCI-H226荷瘤小鼠) 阻止 NF2 缺陷型间皮瘤异种移植物的生长[1]。 Animal Model: | ||||||||||||
| Name | VT104 | ||||||||||||
| CAS | 2417718-25-1 | ||||||||||||
| Formula | C25H19F3N2O | ||||||||||||
| Molar Mass | 420.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. [2]. Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715. |