| Bioactivity | VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production[1]. |
| Invitro | VS-15 通过负面干扰 IDO1 与 SHPs 和 PI3K 调节亚单位 p85 的合作关系，以及 IDO1 在肿瘤细胞早期内体的锚定，来减少 IDO1 介导的信号通路[1]。VS-15 抵消了 TGF-β 介导的树突状细胞的免疫抑制表型，并减少了由胰腺癌患者分离的抑制性单核细胞对 T 细胞增殖的抑制水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VS-15 相关抗体: |
| CAS | 951948-78-0 |
| Formula | C29H27N5O3 |
| Molar Mass | 493.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Eleonora Panfili, et al. Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1. ACS Pharmacol Transl Sci. 2024 Sep 12;7(10):3056-3070. |