| Bioactivity | VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50 value of 19 μM and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1]. |
| Invitro | VRT-534 (Compound 3) (50 μM; 24h) 可以恢复 HeLa 细胞的活力[1]。 Cell Viability Assay[1] Cell Line: |
| Name | VRT-534 |
| CAS | 926664-32-6 |
| Formula | C25H24ClN3O4S |
| Molar Mass | 497.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6(7):997-1005. |
VRT-534
CAS: 926664-32-6 F: C25H24ClN3O4S W: 497.99
VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188
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