Bioactivity | H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH has potential applications in MMP substrates[1][2][3]. |
Name | VPLSLYSG |
CAS | 425632-67-3 |
Sequence | Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly |
Shortening | VPLSLYSG |
Formula | C39H62N8O12 |
Molar Mass | 834.96 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Suzuki H, et al. Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase. ACS Chem Biol. 2008 Aug 15;3(8):471-9. [2]. Patterson J, et al. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials. 2010 Oct;31(30):7836-45. [3]. Wieduwild R, et al. Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions. Biomaterials. 2018 Oct;180:253-264. |