| Bioactivity | VL285 Phenol is a VL285 analogue with Phenol group. VL285, a small molecule VHL ligand, can be served as a degrader for HaloPROTAC3 synthesis.VL285 degrades HaloTag7 fusion proteins (IC50=0.34 μM)[1]. | ||||||||||||
| Invitro | VL285（100 μM；24 小时）减弱 HaloPROTAC3 诱导 GFP-HaloTag7 降解的能力[1]。 | ||||||||||||
| Name | VL285 Phenol | ||||||||||||
| CAS | 1448188-69-9 | ||||||||||||
| Formula | C29H32N4O5S | ||||||||||||
| Molar Mass | 548.65 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. |
VL285 Phenol
CAS: 1448188-69-9 F: C29H32N4O5S W: 548.65
VL285 Phenol is a VL285 analogue with Phenol group. VL285, a small molecule VHL ligand, can be served as a degrader for
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