| Bioactivity | VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) with a Ki value of 0.55 nM and SARS-CoV-2 3CLpro (3CL-PR) with a Ki value of 2.6 nM. VK13 exhibits anti-CoV-2 activity with an EC50 of 1.25 μM[1]. |
| Target | Ki: 2.6 nM (hCatL). Ki: 0.55 nM (3CL-PR). |
| Formula | C24H28N4O5 |
| Molar Mass | 452.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kumar V, et al. Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents. J Am Chem Soc. 2025 Jan 15;147(2):1631-1648. |