| Bioactivity | VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1]. |
| In Vivo | VK-II-86 在低钾血症小鼠全心模型中显著减少非持续性和持续性室性快速心律失常的数量[1]。 |
| Name | VK-II-86 |
| CAS | 955371-84-3 |
| Formula | C25H28N2O4 |
| Molar Mass | 420.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Robinson VM, et al. A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects. Br J Pharmacol. 2022 Jun;179(11):2713-2732. |