| Bioactivity | VK-1727 is a selective small molecule inhibitor of EBNA1. VK-1727 can reduce EBNA1 DNA binding activity. VK-1727 selectively blocks the proliferation and metabolic activity of EBV+ cells, instead of EBV- cells. VK-1727 is used in multiple sclerosis research[1]. |
| Invitro | VK-1727 (25 μM, 72 小时) 显著降低了 EBV+ 细胞中 G2 细胞总数[1]。 0 --> VK-1727 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| Name | VK-1727 |
| Formula | C29H25NO4 |
| Molar Mass | 451.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Monaco MCG, et al. EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls. Neurol Neuroimmunol Neuroinflamm. 2023 Aug 10;10(5):e200149. |